Topic 8 :Viral Infections and Pathogenesis

A. VIDEOS

1. Infection basics
2. Acute infections
3. Persistent infections (Lecture)
4. The infected cell
5. Pathogenesis of viral infection
6. Mechanisms of pathogenesis
7. Transformation and oncogenesis

   B. LEARNING OUTCOMES

   By the end of this topic, students should be able to:

   1. Define viral infection and pathogenesis and explain their significance in disease development.

   2. Describe the routes of viral entry and transmission in animal and human hosts.

   3. Explain the steps involved in the pathogenesis of viral infections, including entry, spread, tissue tropism, and host damage.

   4. Differentiate between local and systemic viral infections.

   5. Explain cytopathic effects (CPEs) and mechanisms of virus-induced cell injury.

   6. Describe host immune responses to viral infections, including innate and adaptive immunity.

   7. Explain mechanisms of viral immune evasion.

   8. Differentiate acute, chronic, latent, and persistent viral infections.

   9. Relate viral virulence and host factors to disease severity and outcome.

   10. Apply knowledge of viral pathogenesis to disease prevention, control, and therapeutic strategies.

C. SUBTOPICS/LESSONS

1. Lesson 1: Viral infections
2. Lesson 1a: Mechanisms of viral infections
3. Lesson 1b: Sequence of virus spread in the host
4. Lesson 1c: Chain of viral infections
5. Lesson 1d: Types and patterns of viral infections
6. Lesson 2: Pathogenesis of viral infections
7. Lesson 2a: A model for studying viral pathogenesis
8. Lesson 2b: Cellular pathogenesis
9. Lesson 2c: Mechanisms of viral oncogenesis

D. STUDY QUESTIONS

1. Study quetions-1
2. Study questions-2