Topic 8 :Viral Infections and Pathogenesis
Learning Objectives On completing this topic, you should be able to: Describe the course is taken by different virus infections Explain the concept of pathogenesis in the context of virus…
Lesson 1: Viral Infections
Viral infection is a proliferation of a virus inside the body after invading normal living cells Many viral infections are asymptomatic or inapparent Iceberg Concept of Viral Infection
Lesson 1a: Mechanisms of viral infections
Three requirements for ensuring a successful infection Sufficient virus particles must be available The cells at the primary site of infection must be accessible, susceptible, and permissive The local host…
Lesson 1d: Types and patterns of viral infections
Five types of virus infections (lytic, persistent, latent, transforming and abortive) are illustrated with emphasis on the progeny virus production and the state of the viral genome (red). The virus…
Lesson 2: Pathogenesis of Viral Infection
The learning objectives of studying the pathogenesis of viral infections often focus on understanding the the mechanisms that lead to disease. Specifically how how viral infections lead to cell death…
Lesson 2a: A model for studying viral pathogenesis
Frank Fenner’s classic study of the pathogenesis of ectromelia (mousepox) viral infection Frank Fenner’s classic study on the pathogenesis of ectromelia virus (mousepox) significantly advanced our understanding of viral infections,…
Lesson 2b: Cellular Pathogenesis
The effects of virus infection on the host cell 1-Cytocidal (death of infected cell) A cell can be directly killed by the virus, The virus kills the cell by Inhibition…
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