A model for studying viral pathogenesis

Frank Fenner’s classic study of the pathogenesis of ectromelia (mousepox) viral infection

1. Initial entry and replication at the local site of entry ±involvement of regional draining lymph nodes
2. Primary viremia, leading to replication in liver and spleen
3. Secondary viremia, with localization in the target organ(s)
4. Replication in the target organ, leading to damage and symptoms
5. Adaptive immune response, clearance of infected cells, elimination of the virus, repair of damage