SOKOINE UNIVERSITY OF AGRICULTURE
COLLEGE OF VETERINARY AND MEDICAL SCIENCES
UNIVERSITY EXAMINATION FOR 2nd YEAR BACHELOR OF VETERINARY MEDICINE
| Course Ante: VM 235
Course Title: VETERINARY VIROLOGY |
DATE: 03 February 2023 TIME: 15:00-18:00 HRS
INSTRUCTIONS: ATTEMPT ALL QUESTIONS
Use well labeled diagrams where necessary
VENUE: MLT 17 & 18
QUESTION ONE (25 Marks)
Provide a brief explanation for the following scenarios in relation to virus infection and transmission (Each 5 marks)
a) A virus is a piece of bad news wrapped up in a protein
b) Viruses are capable of replicating only inside susceptible and permissive cells
b) Some viruses replicate exclusively in the cytoplasm and others in the nucleus
c) Mosquitoes are capable of transmitting malaria parasites to human but are unable to transmit HIV to human
d) Some people have shown to be resistant to HIV infection
QUESTION TWO (25 Marks)
a) Describe the mechanisms used by viruses to enter the cell for replication (15 marks)
b) Use a well labelled diagram only to illustrate how the different groups of viruses (based on Baltimore classification) synthesize mRNA and protein (10 marks)
QUESTION THREE (25 Marks)
a) Describe all the effects of virus infection on the host cell (20 marks)
b) Provide one example of a virus responsible for each effect described in “a” above (5 marks)
QUESTION FOUR (25 Marks)
Answer the following questions below (a-e) in relation to rabies virus, containing a negative sense single-stranded RNA genome of about 11-15 kb surrounded by a protein coat and an envelope.
a) State whether or not the virus packages any enzyme for replication and transcription. If yes, name it. (5 marks)
b) Where does genome replication of rabies virus take place in the infected cell? (2 marks)
c) Describe how the virus exit the infected cell? (8 marks)
d) Name one effect caused by the virus to the cell (2 marks)
e) Describe how vaccinating animals and humans against rabies may prevent future infections (8 marks)
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